Invivocue - Humanized Mice
Invivocue was formed as a joint venture between Invitrocue and Dr Chen Qing Feng, a Principal Investigator at A*STAR Singapore, Institute of Molecular and Cell Biology, whose research expertise focuses on humanized mouse models for various disease applications.
For more details, please visit Invivocue website at www.invivocue.com.
Humanized Mice Products and Services for Unmet Needs in Preclinical Research
We understand the importance of accurately predicting how drugs will work in humans before they are tested in clinical trials. To help you overcome these obstacles, we offer cutting-edge humanized mice models that provide innovative and translational preclinical data for drug discovery. These models allow you to make better predictions about the efficacy and toxicity of your drug candidates.
Invivocue’s proprietary HiMice are a humanised mouse model with a stably reconstituted human immune system. As HiMice express the human immune system, they are an ideal in vivo animal model for research in human immunology, oncology, inflammation and infectious diseases.
Mouse model with a stably reconstituted human immune system.
Background: NOD-SCID IL2rg-/-
Humanization method : CD34+ hematopoietic stem cells (HSCs)
Human Immune System:
hCD45: 20-60% (blood); >80% (spleen)
hCD45 Absolute count: >300 cell/µL
T-cell: 20-60%
B-cell: 20-60%
Myeloid : 0-5%
NK: 0-5%
Mouse model repopulated with human hepatocyte.
Background: : Fah-/- NOD-SCID IL2rg-/-
Humanization method : Primary Human Hepatocytes
Human Immune System: N.A
Human Liver: >70% repopulated
Mouse model with a stably reconstituted human immune system and human hepatocyte.
Background: : Fah-/- NOD-SCID IL2rg-/-
Humanization method : CD34+HSC and Primary Human Hepatocytes
Human Immune System:
hCD45: 20-60% (blood); >80% (spleen)
hCD45 Absolute count: >300 cell/µL
T-cell: 20-60%
B-cell: 20-60%
Myeloid : 0-5%
NK: 0-5%
Human Liver: >70% repopulated
Improves mainly monocytes in 6-weeks old HiMice
Background: NOD-SCID IL2rg-/-
Humanization method : CD34+ hematopoietic stem cells (HSCs)
T-cell: 5-10%
B-cell: 15-25%
Monocytes: 25-35%
NK: 0-5%
GM3 supplementation improves overall reconstitution of immune cells including T cells and monocytes in adult HiMice
Background: NOD-SCID IL2rg-/-
Humanization method : CD34+ hematopoietic stem cells (HSCs)
T-cell: 20-60%
B-cell: 20-60%
Monocytes: 10-20%
NK: 0-5%
IL-15 supplementation improves NK cell population in adult HiMice
Background: NOD-SCID IL2rg-/-
Humanization method : CD34+ hematopoietic stem cells (HSCs)
T-cell: 20-60%
B-cell: 20-60%
Monocytes : 0-5%
NK: 5-20%
Why humanized mice are needed?
Species-Specific Infection
Many infectious organisms exclusively infect humans. Humanized mice provide a valuable platform to study these pathogens and their interactions with the human immune and liver systems.
1
Human-Specific Immune Responses
Many inflammatory and immune responses are unique to humans. The human immune system exhibits specific cytokines, cell surface markers, and cell interactions, which significantly affect disease progression and responses to treatments.
2
Tumor Microenvironment
The interaction between tumors and the immune system is crucial in regulating tumorigenesis and drug responses. Together with human tumor transplantation, the presence of a human-like tumor environment enhances the understanding and development of cancer therapies.
3
Applications of Humanized Mice
Humanized mice are valuable tools in preclinical research, particularly in oncology, immunology, and infectious diseases. By closely mimicking human immune and liver physiological conditions, humanized mice enhance the predictive accuracy of preclinical studies and facilitate the investigation of disease mechanisms and drug development. Here are some key applications:
