Establishment of patient-derived tumor spheroids for non-small cell lung cancer.

PLoS One. 2018 Mar 15;13(3):e0194016. doi: 10.1371/journal.pone.0194016. eCollection 2018. | View Link


Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma.

Nat Med. 2017 Oct;23(10):1167-1175. doi: 10.1038/nm.4401. Epub 2017 Sep 18. | View Link


Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time.

Nat Commun. 2017 Sep 5;8(1):435. doi: 10.1038/s41467-017-00451-5. | View Link


Functionally Enhanced Human Stem Cell Derived Hepatocytes in Galactosylated Cellulosic Sponges for Hepatotoxicity Testing.

Mol Pharm. 2016 Jun 6;13(6):1947-57. doi: 10.1021/acs.molpharmaceut.6b00119. Epub 2016 May 24. | View Link


Testing chemotherapy efficacy in HER2 negative breast cancer using patient-derived spheroids.

J Transl Med. 2016 May 3;14(1):112. doi: 10.1186/s12967-016-0855-3. | View Link

Observational study to compare in vitro sensitivity to therapy in patients-derived organoids (PDOs) with real life outcome: The ChemoSenPDO study

2021 European Society for Medical Oncology. Published by Elsevier Inc. | View Link

Breast cancer organoids mimic disease heterogeneity, allow high-throughput drug screening and show correlation with clinical response

2022 European Society for Medical Oncology. Published by Elsevier Inc. All rights reserved. | View Link

Patient-derived lung cancer organoids for the selection of therapeutic options in an ALK-rearranged tumor

2021 by American Society of Clinical Oncology | View Link

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer.

Cancer Cell. 2018 Jan 8;33(1):75-90.e7. doi: 10.1016/j.ccell.2017.11.007. Epub 2017 Dec 14. PMID: 29249692 | View Link

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.

Nat Med. 2018 Jul;24(7):954-960. doi: 10.1038/s41591-018-0024-8. Epub 2018 May 28. PMID: 29808009 | View Link

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.

Cell Stem Cell. 2021 Jun 3;28(6):1105-1124.e19. doi: 10.1016/j.stem.2021.03.005. Epub 2021 Apr 28. PMID: 33915078 | View Link

Mesenchymal Plasticity Regulated by Prrx1 Drives Aggressive Pancreatic Cancer Biology

Gastroenterology. 2021 Jan;160(1):346-361.e24. doi: 10.1053/j.gastro.2020.09.010. Epub 2020 Sep 30. PMID: 33007300 | View Link

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.

Nat Biomed Eng. 2021 Nov;5(11):1246-1260. doi: 10.1038/s41551-021-00737-6. Epub 2021 Jun 3. PMID: 34083764 | View Link

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness.

Cancer Discov. 2018 Nov;8(11):1458-1473. doi: 10.1158/2159-8290.CD-18-0046. Epub 2018 Sep 5. PMID: 30185628 | View Link

SUMO pathway inhibition targets an aggressive pancreatic cancer subtype.

Gut. 2020 Aug;69(8):1472-1482. doi: 10.1136/gutjnl-2018-317856. Epub 2020 Jan 30. PMID: 32001555 | View Link

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer.

Cancer Cell. 2018 Nov 12;34(5):863-867. doi: 10.1016/j.ccell.2018.10.010. PMID: 30423300 | View Link

Loss of Wasl improves pancreatic cancer outcome.

JCI Insight. 2020 May 21;5(10):e127275. doi: 10.1172/jci.insight.127275. PMID: 32434991 | View Link

Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer

Cell Mol Gastroenterol Hepatol. 2017 Dec 16;5(3):289-298. doi: 10.1016/j.jcmgh.2017.12.004. eCollection 2018 Mar. PMID: 29541683 | View Link

MTOR inhibitor-based combination therapies for pancreatic cancer.

Br J Cancer. 2018 Feb 6;118(3):366-377. doi: 10.1038/bjc.2017.421. Epub 2018 Jan 2. PMID: 29384525 | View Link

Phosphoproteomics Identifies PI3K Inhibitor-selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance.

Mol Cancer Ther. 2021 Dec;20(12):2433-2445. doi: 10.1158/1535-7163.MCT-20-0981. Epub 2021 Sep 22. PMID: 34552006 | View Link

Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.

EMBO Mol Med. 2021 Apr 9;13(4):e12461. doi: 10.15252/emmm.202012461. Epub 2021 Mar 5. PMID: 33665961 | View Link

Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology.

JCI Insight. 2020 Aug 6;5(15):e137809. doi: 10.1172/jci.insight.137809. PMID: 32614802 | View Link

Datasets describing the growth and molecular features of hepatocellular carcinoma patient-derived xenograft cells grown in a three-dimensional macroporous hydrogel.

Data Brief. 2018 Mar 17;18:594-606. doi: 10.1016/j.dib.2018.03.045. eCollection 2018 Jun. | View Link


3D Culture as a Clinically Relevant Model for Personalized Medicine.

SLAS Technol. 2017 Jun;22(3):245-253. doi: 10.1177/2472630317697251. Epub 2017 Mar 9. | View Link


Heralding a new paradigm in 3D tumor modeling.

Biomaterials. 2016 Nov;108:197-213. doi: 10.1016/j.biomaterials.2016.08.052. Epub 2016 Sep 2. | View Link


Generation of mature kupffer cells from human induced pluripotent stem cells.

Biomaterials. 2018 Nov 16;192:377-391. doi: 10.1016/j.biomaterials.2018.11.016. | View Link


Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model.

J Appl Toxicol. 2016 Feb;36(2):320-9. doi: 10.1002/jat.3189. Epub 2015 Jul 21. | View Link


Constrained spheroids for prolonged hepatocyte culture.

Biomaterials. 2016 Feb;80:106-120. doi: 10.1016/j.biomaterials.2015.11.036. Epub 2015 Dec 3. | View Link


HepaRG culture in tethered spheroids as an in vitro three-dimensional model for drug safety screening.

J Appl Toxicol. 2015 Aug;35(8):909-17. doi: 10.1002/jat.3090. Epub 2014 Dec 15. | View Link


Scalable spheroid model of human hepatocytes for hepatitis C infection and replication.

Mol Pharm. 2014 Jul 7;11(7):2106-14. doi: 10.1021/mp500063y. Epub 2014 May 6. | View Link


Tethered spheroids as an in vitro hepatocyte model for drug safety screening.

Biomaterials. 2012 Mar;33(7):2165-76. doi: 10.1016/j.biomaterials.2011.12.006. Epub 2011 Dec 19. | View Link


Galactosylated cellulosic sponge for multi-well drug safety testing.

Biomaterials. 2011 Oct;32(29):6982-94. doi: 10.1016/j.biomaterials.2011.05.087. Epub 2011 Jul 8. | View Link


A robust high-throughput sandwich cell-based drug screening platform.

Biomaterials. 2011 Feb;32(4):1229-41. doi: 10.1016/j.biomaterials.2010.09.064. Epub 2010 Oct 23. | View Link


3D hepatocyte monolayer on hybrid RGD/galactose substratum.

Biomaterials. 2006 Nov;27(33):5669-80. Epub 2006 Aug 10. | View Link

Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy.

Nat Commun. 2018 Nov 22;9(1):4931. doi: 10.1038/s41467-018-07261-3. | View Link


Cancer patients as frequent attenders in emergency departments: A national cohort study.

Cancer Med. 2018 Sep;7(9):4434-4446. doi: 10.1002/cam4.1728. Epub 2018 Aug 17. | View Link


GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.

Oncogene. 2018 Mar;37(10):1340-1353. doi: 10.1038/s41388-017-0038-6. Epub 2017 Dec 19. | View Link


Intertumor heterogeneity of non-small-cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics.

Int J Cancer. 2014 Sep 1;135(5):1092-100. doi: 10.1002/ijc.28750. Epub 2014 Apr 3. | View Link

Neuropilin-1 is upregulated by Wnt/β-catenin signaling and is important for mammary stem cells.

Sci Rep. 2017 Sep 8;7(1):10941. doi: 10.1038/s41598-017-11287-w. | View Link


Identification of blood vascular endothelial stem cells by the expression of protein C receptor.

Cell Res. 2016 Oct;26(10):1079-1098. doi: 10.1038/cr.2016.85. Epub 2016 Jul 1. | View Link


Mammary Development and Breast Cancer: A Wnt Perspective.

Cancers (Basel). 2016 Jul 13;8(7). pii: E65. doi: 10.3390/cancers8070065. | View Link


Identification of multipotent mammary stem cells by protein C receptor expression.

Nature. 2015 Jan 1;517(7532):81-4. doi: 10.1038/nature13851. Epub 2014 Oct 19. | View Link


R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal.

Genes Dev. 2014 Oct 15;28(20):2205-18. doi: 10.1101/gad.245142.114. Epub 2014 Sep 26. | View Link


SLIT/ROBO2 signaling promotes mammary stem cell senescence by inhibiting Wnt signaling.

Stem Cell Reports. 2014 Sep 9;3(3):385-93. doi: 10.1016/j.stemcr.2014.07.007. Epub 2014 Aug 28. | View Link


Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture.

Cell Stem Cell. 2010 Jun 4;6(6):568-77. doi: 10.1016/j.stem.2010.03.020. | View Link

Diagnosis of pathological complete response to neoadjuvant chemotherapy in breast cancer by minimal invasive biopsy techniques.

Br J Cancer. 2015 Dec 1;113(11):1565-70. doi: 10.1038/bjc.2015.381. Epub 2015 Nov 10. | View Link


FemZone trial: a randomized phase II trial comparing neoadjuvant letrozole and zoledronic acid with letrozole in primary breast cancer patients.

BMC Cancer. 2014 Feb 5;14:66. doi: 10.1186/1471-2407-14-66. | View Link


Neoadjuvant letrozole in postmenopausal estrogen and/or progesterone receptor positive breast cancer: A phase IIb/III trial to investigate optimal duration of preoperative endocrine therapy.

BMC Cancer. 2008 Feb 26;8:62. doi: 10.1186/1471-2407-8-62. | View Link

Sequential inhibitor therapy in CML: in vitro simulation elucidates the pattern of resistance mutations after second- and third-line treatment.

Clin Cancer Res. 2013 Jun 1;19(11):2962-72. doi: 10.1158/1078-0432.CCR-13-0052. Epub 2013 Apr 2. | View Link


Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.

Cancer Cell. 2013 Jan 14;23(1):77-92. doi: 10.1016/j.ccr.2012.12.003. | View Link


The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro.

Oncogene. 2011 Feb 24;30(8):933-43. doi: 10.1038/onc.2010.476. Epub 2010 Oct 25. | View Link


Oncologist’s/haematologist’s view on the roles of pathologists for molecular targeted cancer therapy.

J Cell Mol Med. 2010 Apr;14(4):805-17. doi: 10.1111/j.1582-4934.2010.01032.x. Epub 2010 Feb 16. | View Link

The clinical impact of using complex molecular profiling strategies in routine oncology practice.

Oncotarget. 2018 Apr 17;9(29):20282-20293. doi: 10.18632/oncotarget.24757. eCollection 2018 Apr 17. | View Link


The potential predictive value of DEK expression for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer.

BMC Cancer. 2018 Feb 6;18(1):144. doi: 10.1186/s12885-018-4048-8. | View Link


Dysregulation of EGFR Pathway in EphA2 Cell Subpopulation Significantly Associates with Poor Prognosis in Colorectal Cancer.

Clin Cancer Res. 2017 Jan 1;23(1):159-170. doi: 10.1158/1078-0432.CCR-16-0709. Epub 2016 Jul 11. | View Link


Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM).

Clin Transl Oncol. 2012 Oct;14(10):726-39. doi: 10.1007/s12094-012-0856-5. Epub 2012 Jul 27. | View Link


Selection of extreme phenotypes: the role of clinical observation in translational research.

Clin Transl Oncol. 2010 Mar;12(3):174-80. | View Link


Treatment recommendations for metastatic colorectal cancer.

Clin Transl Oncol. 2011 Mar;13(3):162-78. | View Link


Semi-mechanistic description of the in-vitro antiproliferative effect of different antitumour agents.

J Pharm Pharmacol. 2008 Jan;60(1):77-82. | View Link


Moving forward in colorectal cancer research, what proteomics has to tell.

World J Gastroenterol. 2007 Nov 28;13(44):5813-21. | View Link


MRI evaluation of breast cancer.

N Engl J Med. 2007 Jul 12;357(2):191. | View Link

Characteristic Gene Expression Profiles of Human Fibroblasts and Breast Cancer Cells in a Newly Developed Bilateral Coculture System.

Biomed Res Int. 2015;2015:960840. doi: 10.1155/2015/960840. Epub 2015 Jun 11. | View Link


Development of breast cancer therapy: biomarker-driven and response-guided approaches in a neoadjuvant setting.

Int J Biol Markers. 2015 Apr-Jun;30(2):e252-3. | View Link


Tumor angiogenesis: pericytes and maturation are not to be ignored.

J Oncol. 2012;2012:261750. doi: 10.1155/2012/261750. Epub 2011 Oct 9. | View Link

The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers.

Oncotarget. 2015 May 20;6(14):12763-73. | View Link


Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists.

Cell Death Dis. 2018 Oct 22;9(11):1081. doi: 10.1038/s41419-018-1125-5. | View Link


The interleukin-8 pathway in cancer.

Clin Cancer Res. 2008 Nov 1;14(21):6735-41. doi: 10.1158/1078-0432.CCR-07-4843. | View Link