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Hepatitis B Infection Models
Invitrocue has established both 2D and 3D cultures of primary human hepatocytes and established cells e.g HEPAD38 to support HBV drugs development. Monocultures, co-cultures and tri-cultures of hepatocyte, stellate and Kupffer cells were studied extensively and showed promising high HBsAg released and viral DNA. The cells are suitable for long-term study of HBV.
3D mixed culture showed good HBsAg and DNA expression in long-term Hepatitis B Infection up to Day 50.