Scientific Publications

Generation of Matched Patient-Derived Xenograft Models Using In Vitro-In Vivo 3D Macroporous Hydrogels for the Study of Liver Cancer

Fong ELS, Toh TB, Lin QXX, Liu Z, Hooi L, Mohd Abdul Rashid MB, Benoukraf T, Chow EK, Huynh TH, Yu H.

Biomaterials. 2018 Mar. Published on: 2018 | View Link

Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma

Tan DSW, Chong FT, Leong HS, Toh SY, Lau DP, Kwang XL, Zhang X, Sundaram GM, Tan GS, Chang MM, Chua BT, Lim WT, Tan EH, Ang MK, Lim TKH, Sampath P, Chowbay B, Skanderup AJ, DasGupta R, Iyer NG.

Nat Med. 2017 Oct 23. Published on: 2017 | View Link

Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time

Chia S, Low JL, Zhang X, Kwang XL, Chong FT, Sharma A, Bertrand D, Toh SY, Leong HS, Thangavelu MT, Hwang JSG, Lim KH, Skanthakumar T, Tan HK, Su Y, Hui Choo S, Hentze H, Tan IBH, Lezhava A, Tan P, Tan DSW, Periyasamy G, Koh JLY, Gopalakrishna Iyer N, DasGupta R.

Nat Commun. 2017. Published on: 2017 | View Link

Functionally enhanced human stem cell derived hepatocytes in galactosylated cellulosic sponges for hepatotoxicity testing

Tasnim F, Toh YC, Qu Y, Li H, Phan D, Narmada BC, Ananthanarayanan A, Mittal N, Meng RQ, Yu H.

Mol Pharm. 2016 May 24. Published on: 2016 | View Link

Constrained spheroids for prolonged hepatocyte culture

Tong WH, Fang Y, Yan J, Hong X, Hari Singh N, Wang SR, Nugraha B, Xia L, Fong EL, Iliescu C, Yu H.

Biomaterials. 2016 Feb;80:106-20. doi: 10.1016/j.biomaterials.2015.11.036. Published on: 2016 | View Link

Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model

Xia L, Hong X, Sakban RB, Qu Y, Singh NH, McMillian M, Dallas S, Silva J, Sensenhauser C, Zhao S, Lim HK, Yu H.

J Appl Toxicol. 2016 Feb;36(2):320-9. doi: 10.1002/jat.3189. Published on: 2016 | View Link

ABC gene-ranking for prediction of drug-induced cholestasis in rats

Yauheniya Cherkasa, Michael K. McMillianb,1, Dhammika Amaratungab,2,Nandini Raghavanc, Jennifer C. Sasaki

Toxicology Reports 3. 2016 Jan:252-261. doi:10.1016/j.toxrep.2016.01.009. Published on: 2016 | View Link

HepaRG culture in tethered spheroids as an in vitro three-dimensional model for drug safety screening

Wang Z, Luo X, Anene-Nzelu C, Yu Y, Hong X, Singh NH, Xia L, Liu S, Yu H.

J Appl Toxicol. 2015 Aug;35(8):909-17. doi: 10.1002/jat.3090. Published on: 2015 | View Link

Release of (and lessons learned from mining) a pioneering large toxicogenomics database

Sandhu KS, Veeramachaneni V, Yao X, Nie A, Lord P, Amaratunga D, McMillian MK, Verheyen GR.

Pharmacogenomics. 2015 Jul;16(8):779-801. doi: 10.2217/pgs.15.38. Published on: 2015 | View Link

Scalable spheroid model of human hepatocytes for hepatitis C infection and replication

Ananthanarayanan A, Nugraha B, Triyatni M, Hart S, Sankuratri S, Yu H.

Mol Pharm. 2014 Jul 7;11(7):2106-14. doi: 10.1021/mp500063y. Published on: 2014 | View Link

Tethered spheroids as an in vitro hepatocyte model for drug safety screening

Xia L, Sakban RB, Qu Y, Hong X, Zhang W, Nugraha B, Tong WH, Ananthanarayanan A, Zheng B, Chau IY, Jia R, McMillian M, Silva J, Dallas S, Yu H.

Biomaterials. 2012 Mar;33(7):2165-76. doi: 10.1016/j.biomaterials.2011.12.006. Published on: 2012 | View Link

Purpose-driven biomaterials research in liver-tissue engineering

Ananthanarayanan A, Narmada BC, Mo X, McMillian M, Yu H.

Trends Biotechnol. 2011 Mar;29(3):110-8. doi: 10.1016/j.tibtech.2010.10.006. Published on: 2011 | View Link

A robust high-throughput sandwich cell-based drug screening platform

Zhang S, Tong W, Zheng B, Susanto TA, Xia L, Zhang C, Ananthanarayanan A, Tuo X, Sakban RB, Jia R, Iliescu C, Chai KH, McMillian M, Shen S, Leo H, Yu H.

Biomaterials. 2011 Feb;32(4):1229-41. doi: 10.1016/j.biomaterials.2010.09.064. Published on: 2011 | View Link